Mutagenicity of Condensed Pyridazines with Different Substituents.
نویسندگان
چکیده
منابع مشابه
synthesis and dna interaction studies of new cobalt (ii) complexes containing different dinitrogen aaromatic ligands with calf thymus dna using different spectroscopy methods
در این مطالعه بر هم کنش این چهار کمپلکس با dna تیموس گوساله توسط روش های اسپکتروفتومتری، فلوریمتری، دو رنگ نمائی دورانی، و ویسکوزیمتری بررسی شدند تا اثر استخلاف های متیل بر روی لیگاندهای فنانترولین بررسی گردد.
The Effkrcts of Substituents Introduced into 9 - and DNA Binding AMnity Aminoacridine on Frameshift Mutagenicity
Some derivatives ot' 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding aMnity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding aMnity, whjle {he introdu ¢ tion of chlorine increased them. Halogenated derivatSyes f 1 showed higher toxicity against Saintonella mphiinu...
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The pyridazino[4,5-b]indole (3), which is conveniently available from 3-methylthioindole and the tetrazine (2), undergoes thermally induced inverseelectron-demand Diels-Alder reactions with enamines to afford the cycloalkeneannelated carbazoles (7,8) or the 2-substituted carbazole (9), respectively. We have previously shown that 1,2-diazines annelated to a second π-electron-deficient aromatic r...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1995
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.18.363